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Complement system components involved in MAC inhibition and activation
- Molecular classification
- Complement protein, Immunoglobulin, Enzyme
01
Overview
The complement system is a crucial part of the innate immune system. This entry describes the modulation of the complement system via antibodies, specifically IgG and IgA. IgG antibodies can inhibit the formation of the membrane attack complex (MAC), preventing cell lysis. IgA antibodies activate the complement system via the alternative or lectin pathways, promoting pathogen clearance through opsonization and phagocytosis. Modulation of this system is a potential therapeutic target for infections and autoimmune diseases.
- Other names
- Membrane Attack Complex (MAC)Complement CascadeIgG-mediated MAC inhibitionIgA-mediated complement activation
02
Mechanism of action
Inhibition of membrane attack complex (MAC) formation by IgG antibodies; complement activation and clearance by IgA antibodies via alternative or lectin pathway induction
03
Biological functions
Immune responseComplement activationPathogen clearanceCell lysisOpsonization
04
Disease associations
InfectionAutoimmune diseaseInflammation
05
Safety considerations
Off-target complement activationIncreased susceptibility to infectionAutoimmune reactions
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