Gosset Molecular Classification
Complement protein, Immunoglobulin, Enzyme
Other Names
Membrane Attack Complex (MAC), Complement Cascade, IgG-mediated MAC inhibition, IgA-mediated complement activation
Disease Roles
Complement system components involved in MAC inhibition and activation Overview
The complement system is a crucial part of the innate immune system. This entry describes the modulation of the complement system via antibodies, specifically IgG and IgA. IgG antibodies can inhibit the formation of the membrane attack complex (MAC), preventing cell lysis. IgA antibodies activate the complement system via the alternative or lectin pathways, promoting pathogen clearance through opsonization and phagocytosis. Modulation of this system is a potential therapeutic target for infections and autoimmune diseases.
Mechanism of Action
Inhibition of membrane attack complex (MAC) formation by IgG antibodies; complement activation and clearance by IgA antibodies via alternative or lectin pathway induction
Biological Functions
Immune response
Complement activation
Pathogen clearance
Cell lysis
Opsonization
Disease Associations
Infection
Autoimmune disease
Inflammation
Safety Considerations
- Off-target complement activation
- Increased susceptibility to infection
- Autoimmune reactions