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CoREST Co-repressor Complex
- Molecular classification
- Protein complex, Histone modification, Transcription factor regulator
01
Overview
The CoREST co-repressor complex is a multi-protein epigenetic regulator that plays a central role in gene silencing, particularly of neuron-specific genes in non-neuronal cells and during neural development. The complex is involved in chromatin remodeling and transcriptional repression through the recruitment of various chromatin-modifying enzymes, including histone deacetylases (HDAC1 and HDAC2) and lysine-specific demethylase 1A (LSD1/KDM1A). It interacts with the RE1-silencing transcription factor (REST) to mediate long-term gene silencing by modifying local chromatin structure.
- Other names
- REST corepressorRCOR complex
02
Mechanism of action
Chromatin modification (histone deacetylation and demethylation) leading to gene repression
03
Biological functions
Gene silencingChromatin remodelingRegulation of transcriptionDevelopmental regulationEpigenetic regulation
04
Disease associations
Neurological disordersCancer
05
Safety considerations
Potential for off-target effects due to the broad role of histone modificationsComplexity of the complex makes specific targeting challenging
06
Interacting drugs
HDAC inhibitors
1 more in the full profile.
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