Molecular Classification
Protein complex, Histone modification, Transcription factor regulator
Other Names
REST corepressor, RCOR complex
Disease Roles
Neurological disordersCancer

CoREST Co-repressor Complex Overview

The CoREST co-repressor complex is a multi-protein epigenetic regulator that plays a central role in gene silencing, particularly of neuron-specific genes in non-neuronal cells and during neural development. The complex is involved in chromatin remodeling and transcriptional repression through the recruitment of various chromatin-modifying enzymes, including histone deacetylases (HDAC1 and HDAC2) and lysine-specific demethylase 1A (LSD1/KDM1A). It interacts with the RE1-silencing transcription factor (REST) to mediate long-term gene silencing by modifying local chromatin structure.

Mechanism of Action

Chromatin modification (histone deacetylation and demethylation) leading to gene repression

Biological Functions

Gene silencing
Chromatin remodeling
Regulation of transcription
Developmental regulation
Epigenetic regulation

Disease Associations

Neurological disorders
Cancer

Safety Considerations

  • Potential for off-target effects due to the broad role of histone modifications
  • Complexity of the complex makes specific targeting challenging

Interacting Drugs

HDAC inhibitors
LSD1 inhibitors