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Target intelligence / Profile preview
Coronavirus Spike Glycoprotein (SARS-CoV-2 S Protein) (SARS-CoV-2 S Protein)
- Target
- SARS-CoV-2 S Protein
- Molecular classification
- Glycoprotein, Fusion protein, Viral protein
01
Overview
The coronavirus spike glycoprotein, commonly referred to as the S protein, is the largest of the four major structural proteins found in coronaviruses, including SARS-CoV-2. It forms trimeric structures that protrude from the viral envelope and are responsible for giving coronaviruses their characteristic "crown-like" appearance under electron microscopy. The S protein is a class I fusion protein essential for mediating viral entry into host cells by binding to cellular receptors and facilitating membrane fusion.
- Other names
- Spike proteinS proteinCoV_S1
02
Mechanism of action
N/A
03
Biological functions
Host cell entryReceptor bindingMembrane fusionImmune evasion
04
Disease associations
InfectionCOVID-19 pathogenesis
05
Safety considerations
Antibody-dependent enhancement (ADE)Potential for mutations affecting vaccine efficacyEliciting autoimmunity
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