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Target intelligence / Profile preview
COX10 antisense RNA 1 (non-protein coding) (COX10-DT)
- Target
- COX10-DT
- Molecular classification
- Long non-coding RNA (lncRNA)
01
Overview
COX10 antisense RNA 1 (COX10-DT) is a long non-coding RNA gene that is transcribed divergently relative to the protein-coding COX10 gene. COX10-DT does not regulate COX10 directly but functions primarily as a competitive endogenous RNA, sponging miR-206 and thereby regulating the expression of brain-derived neurotrophic factor (BDNF). It is commonly overexpressed in breast cancer tissues, where it promotes cell proliferation and migration, supporting tumor progression. Current data show it may serve as a potential diagnostic or prognostic biomarker, and its involvement in oncogenic pathways makes it a possible therapeutic target for future RNA-based therapies. There is no evidence for clinical drug interaction or established safety concerns in humans at this time.
- Other names
- COX10 divergent transcriptCOX10-ASCOX10-AS1COX10ASCOX10 antisense RNA (non-protein coding)COX10 antisense RNA 1 (non-protein coding)
02
Biological functions
Cell proliferationCell migrationCompetitive endogenous RNA (ceRNA) regulation (sponging miR-206)
03
Disease associations
Cancer (with specific evidence in breast cancer)
04
Biomarkers
Overexpression in breast cancer tissue (potential diagnostic and prognostic biomarker)
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