Creatine Kinase B-type (CKB)

Creatine Kinase B-type Overview

Creatine kinase B-type (CKB), also known as brain-type creatine kinase or CK-BB, is a cytosolic enzyme encoded by the CKB gene in humans. It plays a central role in cellular energy homeostasis and is involved in several physiological and pathological processes. CKB catalyzes the reversible transfer of phosphate groups between ATP and creatine or phosphocreatine (PCr) and ADP, regenerating ATP from ADP. It is critical for tissues with high fluctuating energy demands. Beyond its metabolic function, CKB regulates adaptive thermogenesis, suppresses ferroptosis, and inhibits epithelial-mesenchymal transition (EMT). Overexpression is observed in certain cancers, and it may regulate immune cell activation/development.

Mechanism of Action

Biological Functions

Safety Considerations

Associated Biomarkers