Molecular Classification
Enzyme, Transferase, Kinase
Other Names
Creatine Kinase, CK, Phosphocreatine kinase
Disease Roles
Myocardial infarctionRhabdomyolysisMuscular dystrophy

Creatine Phosphokinase Overview

Creatine phosphokinase (CPK), also known as creatine kinase (CK), is an enzyme that catalyzes the reversible transfer of a phosphate group from ATP to creatine, producing phosphocreatine and ADP. This reaction is crucial for rapid ATP regeneration in tissues with high energy demands, such as skeletal muscle, heart muscle, and brain. Elevated CPK/CK levels in the blood serve as important biomarkers for tissue damage, particularly in myocardial infarction, rhabdomyolysis, and muscular dystrophy. Different isoenzymes (CK-MM, CK-MB, CK-BB) can help localize the source of injury.

Mechanism of Action

N/A

Biological Functions

Energy metabolism
ATP regeneration
Intracellular energy transport
Phosphorylation

Disease Associations

Myocardial infarction
Rhabdomyolysis
Muscular dystrophy
Myopathies
Cardiovascular disease
Tissue injury

Safety Considerations

  • Elevated levels can indicate serious tissue damage
  • Variations due to strenuous exercise or medications

Interacting Drugs

Statins

Associated Biomarkers

Biomarker
Elevated CPK/CK levels in blood
CK-MM (muscle)
CK-MB (heart)
CK-BB (brain)