Crimean-Congo hemorrhagic fever virus glycoprotein (GP38), glycoprotein Gn, glycoprotein Gc, and nucleocapsid protein (N) (CCHFV GP38, CCHFV Gn, CCHFV Gc, CCHFV N)

Crimean-Congo hemorrhagic fever virus antigens encompass viral proteins recognized by the host immune system during infection, notably the glycoproteins (GP38, Gn, Gc) embedded in the viral envelope and the nucleocapsid protein (N). The glycoproteins facilitate viral entry and membrane fusion, with Gc serving as the primary target for neutralizing antibodies. GP38 is a secreted glycoprotein with demonstrated immunogenicity and protective antibody responses in animal models. The nucleocapsid protein is responsible for encapsidating the viral RNA and is a commonly detected antigen in diagnostic assays. These antigens are collectively targets for vaccine development, diagnostic testing, and experimental antibody therapies against CCHFV.

Other names

Crimean-Congo hemorrhagic fever virus glycoprotein GP38CCHFV Gn protein (glycoprotein N)CCHFV Gc protein (glycoprotein C)CCHFV nucleocapsid protein (N)Crimean-Congo hemorrhagic fever virus N proteinCCHFV antigens (general term)

Neutralizing antibodies targeting glycoprotein Gc block membrane fusion, preventing viral entry; Antibodies against GP38 can confer protective immunity, though precise mechanism not fully defined