Cross-reactive Immunoglobulin E (IgE) and T-cell receptor (TCR) specific for homologous Urticaceae pollen allergens

Cross-reactive Immunoglobulin E (IgE) and T-cell receptors (TCRs) specific for homologous Urticaceae pollen allergens are the primary immunological mediators of allergic sensitization to plants such as Parietaria (pellitory) and Humulus (hop). These receptors recognize highly conserved epitopes on major allergens, particularly the non-specific lipid transfer proteins (nsLTPs) Par j 1 and Par j 2 [1][2]. IgE antibodies bind these allergens and cross-link on the surface of mast cells and basophils via the high-affinity FcεRI receptor, triggering the release of inflammatory mediators like histamine [3]. Simultaneously, TCRs on CD4+ T-cells recognize allergen-derived peptides presented by MHC class II molecules, typically driving a Th2-polarized immune response characterized by the secretion of IL-4, IL-5, and IL-13 [4]. Therapeutic strategies targeting these receptors include monoclonal antibodies like Omalizumab, which neutralizes circulating IgE, and allergen-specific immunotherapy (AIT), which aims to desensitize TCR-mediated responses and induce regulatory T-cell (Treg) populations [5][6].

Other names

Urticaceae-specific Immunoglobulin EParietaria-specific T-cell receptorsPar j 1/Par j 2 specific receptorsCross-reactive pollen allergen receptorsnsLTP-specific IgE and TCR

Neutralization of circulating Immunoglobulin E to prevent mast cell degranulation and desensitization of T-cell responses through allergen-specific immunotherapy to induce regulatory T-cell populations.