Crystallin gamma E, pseudogene (CRYGEP)

Crystallin gamma E, pseudogene (CRYGEP), also known as G2, is a member of the gamma-crystallin gene cluster on human chromosome 2 and is classified as a pseudogene. Unlike its functional counterparts (e.g., gamma A–gamma D crystallins), CRYGEP does not code for a full-length, functional protein under normal circumstances. However, mutations affecting regulatory sequences can reactivate its truncated open reading frame, leading to the production of a shortened 6 kDa N-terminal fragment of gamma-crystallin. Reactivation and aberrant expression of this pseudogene have been associated with the genetic eye disorder hereditary Coppock-like cataract, likely due to accumulation of the faulty protein fragment in the lens. CRYGEP is not considered a druggable molecular target nor does it belong to therapeutic target classes such as receptors or enzymes[1][6].

Other names

CRYG5CCLCRYGEP1G2

None (no mechanism, as it is not a classical drug target)