Gosset Molecular Classification
Protein, Secreted Antigen
Other Names
CFP-10
Disease Roles
Culture Filtrate Protein 10 Overview
Culture Filtrate Protein 10 (CFP-10) is a 10-kDa protein secreted by Mycobacterium tuberculosis. It forms a heterodimeric complex with ESAT-6, which is essential for M. tuberculosis virulence. CFP-10 is highly immunogenic, stimulating T cells and cytokine production, making it a target for diagnostic assays and vaccine development. Recent research shows CFP-10 triggers Ca²⁺ response in neutrophils, indicating proinflammatory activity.
Mechanism of Action
CFP-10 forms a heterodimeric complex with ESAT-6, influencing virulence and immune response through neutrophil activation and cytokine release.
Biological Functions
Immunomodulation
Chaperone for ESAT-6
Proinflammatory activity
T cell stimulation
Cytokine production
Disease Associations
Tuberculosis
Infection
Safety Considerations
No safety concerns listed
Associated Biomarkers
| Biomarker |
|---|
| Diagnostic marker for TB infection |
| Interferon-gamma release assays |