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Target intelligence / Profile preview
Cutibacterium acnes
- Molecular classification
- Bacteria, Actinobacteria
01
Overview
Cutibacterium acnes is a Gram-positive, anaerobic, rod-shaped bacterium that is part of the normal human skin flora. It plays a role in maintaining skin health but can also contribute to acne vulgaris and other infections under certain conditions.
- Other names
- Propionibacterium acnesP. acnes
02
Mechanism of action
Antibiotics inhibit bacterial growth; benzoyl peroxide oxidizes bacterial proteins; retinoids affect keratinization and inflammation.
03
Biological functions
Skin microbiome maintenanceAcid productionInhibition of pathogen growthEpidermal lipid synthesis regulation
04
Disease associations
Acne vulgarisFolliculitisProsthetic joint infectionEndocarditisOsteomyelitisSeptic arthritisChronic prostatitisSarcoidosis
05
Safety considerations
Antibiotic resistanceSkin irritation (benzoyl peroxide, retinoids)Systemic side effects (oral antibiotics)
06
Interacting drugs
Antibiotics (e.g., tetracyclines, macrolides, clindamycin)
2 more in the full profile.
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