CXXC-type zinc finger protein 5 (CXXC5)

Molecular Classification

Transcription factor

Other Names

CF5, RINF, WID, HSPC195

Disease Roles

OsteoporosisAlopecia (hair loss)Impaired wound healing

CXXC-type zinc finger protein 5 Overview

CXXC-type zinc finger protein 5 (CXXC5) is a transcription factor involved in various developmental processes, including myelopoiesis, endothelial differentiation, and oligodendrocyte differentiation. It acts as a negative regulator of the Wnt/β-catenin signaling pathway by interacting with Dishevelled (Dvl). Dysregulation of CXXC5 is associated with diseases like osteoporosis, alopecia, and impaired wound healing. It binds to unmethylated CpG dinucleotides via its CXXC domain, influencing epigenetic regulation. Recent studies implicate it in breast carcinogenesis.

Mechanism of Action

Negative regulation of Wnt/β-catenin signaling via Dvl binding; DNA binding to unmethylated CpG dinucleotides

Biological Functions

Myelopoiesis

Endothelial cell differentiation

Vessel formation

Oligodendrocyte differentiation

Regulation of Wnt/β-catenin signaling

Disease Associations

Osteoporosis

Alopecia (hair loss)

Impaired wound healing

Breast cancer

Safety Considerations

Cytosolic overexpression linked with pathological conditions