Molecular Classification
Signaling pathway
Other Names
Cyclic AMP pathway
Disease Roles
Cyclic adenosine monophosphate pathway Overview
The cyclic adenosine monophosphate (cAMP) pathway is a fundamental intracellular signaling cascade that mediates the effects of numerous extracellular signals, including hormones and neurotransmitters. cAMP acts as a second messenger, relaying signals from cell surface receptors to internal effector systems and regulating diverse physiological processes such as metabolism, gene transcription, immune responses, and cell communication.
Mechanism of Action
Modulation of cAMP levels via adenylate cyclase or phosphodiesterase; activation of downstream effectors like PKA and Epac.
Biological Functions
Signal transduction
Metabolic regulation
Gene expression regulation
Cell communication
Immune modulation
Cardiac pacemaking
Disease Associations
Autoimmune diseases
Other disorders linked with dysregulated signal transduction
Safety Considerations
- Potential for off-target effects due to widespread cAMP signaling.
- Dysregulation can contribute to various diseases.
Interacting Drugs
Epinephrine/adrenaline
Glucagon
Phosphodiesterase inhibitors
PKA modulators
Epac modulators