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Target intelligence / Profile preview
Cyclic AMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A)
- Target
- PDE3A
- Molecular classification
- Enzyme, Phosphodiesterase
01
Overview
Cyclic AMP-inhibited 3',5'-cyclic phosphodiesterase 3A (PDE3A) is an enzyme that hydrolyzes both cAMP and cGMP, regulating their intracellular levels. It plays a crucial role in various physiological processes, including cardiac contractility, platelet function, and oocyte maturation. Mutations in PDE3A are associated with hypertension, and pharmacological inhibitors are used in the treatment of heart failure and platelet disorders, albeit with safety concerns.
- Other names
- CGI-PDE ACyclic GMP-inhibited phosphodiesterase A
02
Mechanism of action
Inhibition of PDE3A leads to increased intracellular cAMP and cGMP levels.
03
Biological functions
Regulation of cAMP levelsRegulation of cGMP levelsCardiac contractility modulationPlatelet activation regulationOocyte maturation controlRegulation of apoptosis
04
Disease associations
Heart failureHypertensionPlatelet disorders
05
Safety considerations
Increased mortality with long-term use of PDE3 inhibitors in heart failure patientsPotential for adverse cardiac remodeling
06
Interacting drugs
PDE3 inhibitors (e.g., milrinone, enoximone)
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