Cyclic nucleotide-gated channel (CNGC)

Cyclic nucleotide-gated channel Overview

Cyclic nucleotide-gated channels (CNGCs) are nonselective cation channels crucial for sensory transduction, especially in vision and olfaction. They are heterotetrameric assemblies of alpha (CNGA1–4) and beta (CNGB1, CNGB3) subunits, each with six transmembrane domains and a cyclic nucleotide-binding domain (CNBD). Activation by cyclic nucleotides induces conformational changes, opening the channel and allowing passage of Na+, K+, Ca2+, and other ions. In plants, CNGCs are involved in Ca2+ signaling pathways related to development, stress, and defense. Mutations in CNGC genes can cause retinal degenerative diseases like achromatopsia.

Mechanism of Action

Directly gated by cAMP/cGMP binding, leading to channel opening and ion flow

Biological Functions

Safety Considerations