Cyclin B ()

Cyclin B Overview

Cyclin B is a key regulatory protein involved in the control of the cell cycle, specifically governing entry into and exit from mitosis (M phase). It functions primarily by forming a complex with cyclin-dependent kinase 1 (CDK1), also known as p34(cdc2), to create the maturation-promoting factor (MPF). Its degradation is required for exit from mitosis via ubiquitination mediated by the anaphase-promoting complex/cyclosome (APC/C), which targets cyclin B for proteasomal degradation. Overexpression or dysregulation of cyclin B has been observed in various cancers and correlates with tumor aggressiveness.

Mechanism of Action

Biological Functions

Safety Considerations