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Target intelligence / Profile preview
Cyclin B
- Molecular classification
- Cyclins
01
Overview
Cyclin B is a key regulatory protein involved in the control of the cell cycle, specifically governing entry into and exit from mitosis (M phase). It functions primarily by forming a complex with cyclin-dependent kinase 1 (CDK1), also known as p34(cdc2), to create the maturation-promoting factor (MPF). Its degradation is required for exit from mitosis via ubiquitination mediated by the anaphase-promoting complex/cyclosome (APC/C), which targets cyclin B for proteasomal degradation. Overexpression or dysregulation of cyclin B has been observed in various cancers and correlates with tumor aggressiveness.
02
Biological functions
Cell cycleRegulation of mitosisChromosome condensationNuclear envelope breakdownSpindle pole assembly
03
Disease associations
Cancer
04
Safety considerations
Overexpression or dysregulation observed in various cancersHigh levels correspond with low levels of tumor suppressor gene p53
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