Gosset Molecular Classification
Pathway, Enzymatic Pathway
Disease Roles
Cyclooxygenase pathway Overview
The cyclooxygenase (COX) pathway is a major metabolic route responsible for converting arachidonic acid into prostanoids (prostaglandins, prostacyclins, and thromboxanes), which play critical roles in inflammation, hemostasis, renal function, and other physiological processes. The central enzymes are cyclooxygenases (COXs), with two main isoforms: COX-1 (constitutive) and COX-2 (inducible). Inhibition of this pathway is a common therapeutic strategy for managing pain and inflammation.
Mechanism of Action
Inhibition of cyclooxygenase enzymes (COX-1 and/or COX-2), leading to reduced prostanoid synthesis.
Biological Functions
Inflammation
Hemostasis
Renal function
Prostanoid synthesis
Disease Associations
Inflammation
Cardiovascular disease
Cancer
Acute kidney injury
Safety Considerations
- Gastrointestinal toxicity (NSAIDs)
- Cardiovascular risks (COX-2 inhibitors)
Interacting Drugs
NSAIDs
COX-2 inhibitors (Coxibs)