Cytidine Deaminase and DNA Polymerase Alpha (Cytarabine Targets) (CDA & POLA)

This entry encompasses both cytidine deaminase (CDA) and DNA polymerase alpha (POLA) as the key targets relevant to the mechanism of action and metabolism of cytarabine. CDA is an enzyme responsible for inactivating cytarabine by deamination. DNA polymerase alpha is inhibited by the active triphosphate form of cytarabine, which gets incorporated into DNA, disrupting DNA synthesis and leading to cell death. This dual mechanism is crucial for cytarabine's antileukemic effects. Genetic variations in CDA can influence the drug's efficacy and toxicity.

Other names

Cytidine Deaminase Substrate / DNA Polymerase Alpha InhibitorAra-C targets

Cytidine deaminase metabolizes/inactivates cytarabine; DNA polymerase alpha is inhibited by cytarabine triphosphate incorporation into DNA during replication, leading to chain termination or faulty elongation.