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Target intelligence / Profile preview
Cytochrome b-245, beta chain (gp91phox)
- Target
- gp91phox
- Molecular classification
- Enzyme, NADPH oxidase subunit
01
Overview
CYBB encodes gp91phox, a critical subunit of the NADPH oxidase enzyme complex in phagocytes. NADPH oxidase generates reactive oxygen species essential for killing pathogens. Mutations in CYBB cause X-linked chronic granulomatous disease (CGD), characterized by recurrent infections and inflammation due to impaired ROS production.
- Other names
- CYBBNOX2Cytochrome b-245 heavy chainp91-phox
02
Mechanism of action
Modulation of NADPH oxidase activity impacting ROS production; potential therapeutic strategies include gene therapy to correct CYBB mutations or pharmacological manipulation of NADPH oxidase activity.
03
Biological functions
Immune responseReactive oxygen species (ROS) productionMicrobial killingPhagocytosis
04
Disease associations
Chronic granulomatous diseaseImmunodeficiency
05
Safety considerations
Over-inhibition of NADPH oxidase could impair immune function and increase susceptibility to infection.Unintended consequences of gene therapy.Potential for off-target effects when using pharmacological inhibitors.
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