Cytochrome c oxidase subunit 5A, mitochondrial (COX5A)

Cytochrome c oxidase subunit 5A, mitochondrial (COX5A), is a nuclear-encoded subunit of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial respiratory chain. The protein is located in the inner mitochondrial membrane, where it is essential for oxidative phosphorylation, facilitating the transfer of electrons from cytochrome c to molecular oxygen, enabling ATP synthesis and maintaining cellular energy. COX5A is implicated in the regulation, assembly, and stability of the enzyme complex. Defects or altered expression of COX5A are associated with complex IV deficiency diseases, neurodegenerative disorders such as Alzheimer’s disease, and altered cell metabolism in cancer. Experimental data suggest COX5A influences neuronal plasticity and is a candidate therapeutic target for conditions of mitochondrial dysfunction

Other names

Cytochrome c oxidase polypeptide VaCOX5ACOX-VAVAMC4DN20

Enzyme inhibition (general for cytochrome c oxidase complex: disruption of electron transfer and ATP synthesis), experimental modulation (possibly via gene expression changes affecting mitochondrial function)