Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1)

Cytochrome c oxidase subunit 6A1, mitochondrial (COX6A1) is a 12 kDa, 109 amino acid structural subunit of cytochrome c oxidase (Complex IV), encoded by nuclear DNA and expressed in non-muscle tissues. COX6A1 forms part of the enzyme complex responsible for the terminal reduction of oxygen to water in the mitochondrial electron transport chain, essential for ATP synthesis. Mutations in COX6A1 cause autosomal recessive Charcot-Marie-Tooth disease and other neuropathies. The subunit is crucial for the proper assembly and regulation of cytochrome c oxidase activity, although it does not directly participate in catalysis. There is no evidence of direct clinical therapeutic targeting of COX6A1, but impairment of its function results in significant mitochondrial dysfunction[1][2][3][4][5][9].

Other names

COX6A1COX6ACOX6ALCMTRIDCytochrome c oxidase polypeptide VIa-liverCytochrome c oxidase subunit VIA-liverCytochrome c oxidase subunit VIa liver isoformCytochrome c oxidase subunit VIa polypeptide 1

HIV-1 Tat: inhibition of overall cytochrome c oxidase activity, leading to loss of membrane potential and release of cytochrome c (apoptosis induction). Mitochondrial electron transport chain inhibitors: block electron flow, induce mitochondrial dysfunction, trigger apoptosis.