Cytochrome c oxidase subunit 7A1 (COX7A1) (COX7A1)

Cytochrome c oxidase subunit 7A1 (COX7A1) is a nuclear-encoded, muscle-specific component of Complex IV, the terminal enzyme of the mitochondrial respiratory chain [1]. It plays a critical role in the assembly and regulation of the cytochrome c oxidase complex, which catalyzes the reduction of oxygen to water and contributes to the proton gradient used for ATP synthesis [1, 2]. COX7A1 is primarily expressed in heart and skeletal muscle, where it modulates metabolic efficiency and energy production [2]. Research indicates that COX7A1 expression is significantly downregulated in the skeletal muscle of individuals with type 2 diabetes and obesity, suggesting its involvement in metabolic dysfunction [3]. Furthermore, it serves as a key marker for the browning of white adipose tissue and is essential for maintaining cardiac function [4]. While there are currently no FDA-approved drugs specifically targeting COX7A1, it is an active area of investigation for metabolic and cardiovascular therapies aimed at restoring mitochondrial function [3, 4].

Other names

Cytochrome c oxidase polypeptide VIIa-muscleCOX7AHCOX7AMCytochrome c oxidase subunit VIIa-HCOX7A1 mRNA

Regulation of the assembly and catalytic activity of the cytochrome c oxidase complex to optimize mitochondrial respiration and energy production.