Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2)

Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2), is a nuclear-encoded structural subunit of complex IV (cytochrome c oxidase) of the mitochondrial respiratory chain[2][3]. Complex IV catalyzes electron transfer from cytochrome c to molecular oxygen and contributes to the proton gradient that drives ATP synthesis via oxidative phosphorylation in mitochondria[2][3]. COX7A2 is widely expressed in both muscle and non-muscle tissues and is distinct from the muscle-specific isoform COX7A1[3][4]. This subunit is thought to play a regulatory and assembly role within complex IV rather than contributing catalytically to electron transfer. Variants and dysregulation of COX7A2 or its complex can be associated with mitochondrial diseases and have been linked to some cancer types as a component of altered mitochondrial function[3]. COX7A2 is not currently recognized as a direct drug target or clinical biomarker, and its effects are understood in the context of the integrity and function of the mitochondrial electron transport chain[2][3][4].

Other names

COX7A2COX7ALCytochrome c oxidase subunit VIIa-LCytochrome c oxidase subunit VIIaLCOXIIa-LCOX7AL1COXIIALVIIALcytochrome c oxidase polypeptide 7A2cytochrome c oxidase polypeptide VIIa-liver/heartcytochrome c oxidase subunit VIIa polypeptide 2 (liver)hepatic cytochrome-c oxidase chain VIIa