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Cytochrome c oxidase subunit 7C, mitochondrial (COX7C)
- Target
- COX7C
- Molecular classification
- Enzyme, Mitochondrial respiratory chain complex subunit, Electron transport chain protein
01
Overview
Cytochrome c oxidase subunit 7C, mitochondrial (COX7C), is a nuclear-encoded structural subunit of cytochrome c oxidase (Complex IV), the terminal enzyme of the mitochondrial electron transport chain, which catalyzes the transfer of electrons from reduced cytochrome c to molecular oxygen, facilitating oxidative phosphorylation and ATP production[1][4][5][6][9]. The subunit itself is not catalytically active but is involved in the assembly, stability, and regulation of the multi-subunit enzyme complex[1]. It is expressed in all tissues[1]. If you require structured or additional details, information on direct drug interactions and uses as a biomarker is limited or not established for this specific subunit.
- Other names
- Cytochrome c oxidase polypeptide VIIcCOX VIIcCOX7C
02
Biological functions
Oxidative phosphorylationMitochondrial electron transport (cytochrome c to oxygen)Cellular respiration
03
Disease associations
Neurodegenerative diseaseMitochondrial diseaseOther (Impaired oxidative phosphorylation is implicated in diverse disorders, but direct links to specific diseases for this subunit may be limited)
04
Safety considerations
Essential for cellular energy production; inhibition or dysfunction can cause severe mitochondrial dysfunctionNot a common direct therapeutic target due to central role in energy metabolism
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