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Target intelligence / Profile preview
Cytochrome P450 2E1 (CYP2E1)
- Target
- CYP2E1
- Molecular classification
- Enzyme, Cytochrome P450, Monooxygenase
01
Overview
Cytochrome P450 2E1 (CYP2E1) is a member of the cytochrome P450 superfamily of enzymes involved in the metabolism of a wide range of compounds. It metabolizes small organic molecules, including ethanol, acetone, and toxic environmental chemicals. CYP2E1 plays a dual role in detoxification and bioactivation of procarcinogens. Its expression is induced by ethanol, diabetes, and starvation, leading to increased metabolic capacity and ROS production. Elevated CYP2E1 activity is implicated in liver diseases, cancer, and heart disease. There are significant inter-individual differences in hepatic CYP2E1 levels, influencing individual responses to drugs and susceptibility to toxic effects.
02
Mechanism of action
N/A
03
Biological functions
Xenobiotic metabolismEthanol metabolismFatty acid metabolismDetoxificationBioactivationROS generation
04
Disease associations
Alcoholic liver diseaseCancerHeart diseaseOxidative stressHepatotoxicity
05
Safety considerations
Drug-drug interactionsBioactivation of procarcinogensROS generationInter-individual variability in expression/activity
06
Interacting drugs
Ethanol
2 more in the full profile.
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