Cytochrome P450 3A4 (None)

Cytochrome P450 3A4 (CYP3A4) is a key enzyme in the cytochrome P450 superfamily, responsible for metabolizing approximately 50-60% of all prescribed drugs and many endogenous compounds, including steroids and fatty acids. It is predominantly expressed in the liver and intestine. Due to its broad substrate specificity, CYP3A4 is a major contributor to drug-drug interactions, with many drugs acting as inhibitors or inducers of its activity. This can lead to altered plasma concentrations of co-administered medications, resulting in therapeutic failure or toxicity. It also has epoxide activity, converting arachidonic acid into epoxyeicosatrienoic acids (EETs) which have roles including cancer cell growth promotion.

Other names

CP33CP34CYP3ACYP3A3CYPIIIA3CYPIIIA4HLPNF-25P450C3P450PCN1VDDR3

CYP3A4 catalyzes monooxygenation reactions, primarily involved in the metabolism of a vast array of xenobiotics and endogenous compounds. It can be inhibited or induced by drugs, altering the metabolism of its substrates.