Cytochrome P450 family 1 subfamily B member 1 (CYP1B1) mRNA (CYP1B1 mRNA)

Cytochrome P450 family 1 subfamily B member 1 (CYP1B1) mRNA is the transcript encoding the CYP1B1 enzyme, a member of the cytochrome P450 superfamily involved in the metabolism of xenobiotics and endogenous substrates. The encoded enzyme is primarily responsible for the 4-hydroxylation of estrogens, producing metabolites that can contribute to cellular damage and oncogenesis [Source: PubMed, PMID: 16112003]. While the protein is essential for the normal development of the eye's anterior segment, its expression is significantly upregulated in various cancers, such as breast, prostate, and lung cancer, while being nearly absent in normal tissues [Source: UniProt, P39905]. This differential expression pattern identifies CYP1B1 mRNA as a high-priority target for RNA-based therapeutic strategies, including small interfering RNAs (siRNAs) and antisense oligonucleotides aimed at reducing tumor-promoting enzyme levels [Source: Cancer Research]. Furthermore, the mRNA sequence is utilized in the development of cancer vaccines and immunotherapies designed to stimulate an immune response against CYP1B1-positive tumor cells [Source: ClinicalTrials.gov]. Mutations in the gene encoding this mRNA are the most common cause of primary congenital glaucoma, highlighting its critical physiological role [Source: NIH, GeneReviews].

Other names

CP1BGLC3ACytochrome P450 1B1CYP1B1

Inhibition of protein expression via RNA interference or antisense knockdown; direct inhibition of the encoded enzyme's catalytic activity; induction of immune response via mRNA/DNA vaccination.