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Cytochrome P450 family 4 subfamily F member 26, pseudogene (CYP4F26P)
- Target
- CYP4F26P
- Molecular classification
- Pseudogene, CYP (Cytochrome P450) family member (non-functional)
01
Overview
CYP4F26P is a member of the cytochrome P450 (CYP) superfamily but classified as a pseudogene, meaning it is a non-functional copy of a gene and does not code for an active protein. Despite historical views of pseudogenes as "junk DNA," recent findings suggest some pseudogenes, including CYP4F26P, may have regulatory RNA-level roles, particularly in the context of cancer. In nasopharyngeal carcinoma, CYP4F26P was reported as significantly down-regulated and may participate in metabolic pathways like arachidonic acid metabolism, potentially impacting tumorigenesis[1]. No evidence supports CYP4F26P as a direct therapeutic target, but it may serve as a biomarker for diagnosis or prognosis in selected cancer types[1][3][4].
- Other names
- CYP4F-se2cytochrome P450, family 4, subfamily F, polypeptide 26, pseudogeneCYP4F26P
02
Mechanism of action
Not applicable; no protein product, so no drug mechanism of action
03
Biological functions
Potential regulatory roles at the RNA level (e.g., gene regulation, competing endogenous RNA), but no enzymatic activityMay be involved in regulation of pathways such as arachidonic acid metabolism in certain cancers
04
Disease associations
Reported as differentially expressed in nasopharyngeal carcinoma (NPC)Potential prognostic indicator for lung squamous cell carcinoma
05
Biomarkers
Has been studied as a biomarker for disease prognosis (e.g., in NPC and lung squamous cell carcinoma)
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