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Target intelligence / Profile preview
Cytomegalovirus (CMV)
- Target
- CMV
- Molecular classification
- Virus, Herpesvirus, Betaherpesvirus, DNA Virus
01
Overview
Cytomegalovirus is a ubiquitous herpesvirus that establishes lifelong latency after primary infection. While generally harmless to healthy individuals—often causing no symptoms—it poses significant risks during pregnancy and among those with weakened immune systems due to its capacity for reactivation and broad tissue tropism. No vaccine exists yet despite ongoing research efforts targeting this important viral pathogen.
- Other names
- Human cytomegalovirusHCMV
02
Mechanism of action
Inhibition of viral DNA polymerase
03
Biological functions
Viral replicationLatency establishmentImmune evasionHost cell modulationViral assemblyViral maturationViral egress
04
Disease associations
InfectionCongenital diseaseImmunodeficiency-related disease
05
Safety considerations
Drug resistanceNephrotoxicity (Cidofovir, Foscarnet)Myelosuppression (Ganciclovir, Valganciclovir)Limited efficacy in certain patient populations
06
Interacting drugs
Antivirals (e.g., Ganciclovir, Valganciclovir, Foscarnet, Cidofovir)
07
Biomarkers
CMV viral load (DNA)CMV pp65 antigenemia
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