Cytomegalovirus immediate-early 1 peptide : HLA class I complex (CMV IE1 peptide : HLA-I complex)

The **Cytomegalovirus immediate-early 1 peptide : HLA class I complex** is a molecular complex that forms when a peptide fragment derived from the immediate-early 1 (IE1) protein of human cytomegalovirus (HCMV) is presented at the cell surface by a human leukocyte antigen (HLA) class I molecule[3][9]. HLA class I molecules are cell-surface receptors responsible for presenting endogenous peptide antigens, typically 8–10 amino acids in length, to cytotoxic CD8+ T cells[2][6]. Presentation of the IE1 peptide enables immune recognition and elimination of CMV-infected cells, making this complex a critical target for antiviral immune responses, monitoring of immunity, and immunotherapy development[3][9]. Multiple HLA class I alleles are capable of presenting distinct IE1 epitopes, with allelic variation influencing immune recognition[3]. The complex is also a principal target of CMV’s immune evasion mechanisms, as HCMV encodes multiple proteins that downregulate surface HLA class I expression or function to escape immune detection[5][7][9]. This makes the CMV IE1 peptide : HLA class I complex both a therapeutic target in infectious diseases and a model system in immunology research.

Other names

HCMV IE1 peptide–HLA class I complexHuman cytomegalovirus IE1 peptide–HLA class I complexHCMV IE1–HLA-I complexCMV IE1–HLA-IHLA class I–CMV IE1 peptide

Elicitation of CD8+ T cell–mediated cytotoxicity against CMV-infected cells through recognition of CMV IE1 peptides presented on HLA class I molecules