Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Cytosine Deaminase (CD)
- Target
- CD
- Molecular classification
- Enzyme, Deaminase
01
Overview
Cytosine deaminase (EC 3.5.4.1) is an enzyme that catalyzes the hydrolytic deamination of cytosine to uracil, releasing ammonia. It is found primarily in bacteria and fungi and plays a key role in pyrimidine salvage pathways. It also acts on certain cytosine analogs, most notably converting the prodrug 5-fluorocytosine into the chemotherapeutic agent 5-fluorouracil. Its absence in mammalian cells and presence in pathogens make it a target for antimicrobial drug design and a key component in cancer gene therapy.
02
Mechanism of action
Hydrolytic deamination of cytosine to uracil
03
Biological functions
Pyrimidine salvageNucleobase conversion
04
Disease associations
InfectionCancer
05
Safety considerations
Off-target effects due to expression in non-tumor cells (gene therapy)Development of resistance to 5-fluorouracil
06
Interacting drugs
5-Fluorocytosine
1 more in the full profile.
Beyond the preview
Go deeper on Cytosine Deaminase (CD).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Cytosine Deaminase (CD).