Cytosolic 5'-nucleotidase 1B (NT5C1B)

Cytosolic 5'-nucleotidase 1B (NT5C1B) is an intracellular enzyme that catalyzes the hydrolysis of nucleotide monophosphates, predominantly AMP, to release inorganic phosphate and the corresponding nucleoside—typically adenosine. As a cytosolic member of the 5'-nucleotidase family, it controls the intracellular levels of AMP and contributes to the regulation of cellular nucleotide pools and adenosine metabolism. The enzyme plays a housekeeping metabolic role rather than being a key drug target or clinical biomarker. Mutations or alterations in NT5C1B activity have been associated with rare genetic syndromes, such as Laurence-Moon syndrome and pontocerebellar hypoplasia, but NT5C1B is not currently a focus of targeted therapeutics, and there are no known drugs that interact specifically with this protein. It is considered functionally important for nucleotide turnover and purine metabolism in various tissues.

Other names

Cytosolic 5'-nucleotidase IBAIRPFKSG85cN1BcN-IBCN-IBCN1BAutoimmune infertility-related proteintesticular tissue protein Li 1

Not applicable (no current drugs directly targeting this enzyme; mechanism is hydrolysis of nucleotide monophosphates)