Target intelligence / Profile preview

Cytotoxic Agent (Various)

Molecular classification: Alkylating Agent, Nitrosourea, Anti-metabolite, Plant Alkaloid, Cytotoxic Antibiotic, Antitumor Antibiotic, Immune-derived cytotoxic proteins

Overview

Cytotoxic agents are substances that kill or damage cells, primarily used in chemotherapy to treat cancer. They work by interfering with essential cellular processes, such as DNA replication, repair, and mitosis. They are also used in autoimmune diseases to suppress immune cell proliferation. Due to their non-selective nature, they also harm healthy cells, leading to various side effects.

Other names: Chemotherapeutic AgentsCytotoxic Drugs

Mechanism of action

Various mechanisms, including DNA damage, inhibition of DNA repair, blocking nucleic acid synthesis, disrupting mitosis, and inducing apoptosis.

Biological functions

Cell deathInhibition of cell proliferationDNA damageInhibition of DNA repairInhibition of nucleic acid synthesisDisruption of mitosisApoptosis induction

Disease associations

CancerAutoimmune Diseases

Safety considerations

MyelosuppressionGastrointestinal toxicityHair lossMucositisCardiomyopathyBladder toxicitySecondary malignancies

Interacting drugs

Cyclophosphamide

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