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Target intelligence / Profile preview
D-Alanyl-D-Alanine (D-Ala-D-Ala)
- Target
- D-Ala-D-Ala
- Molecular classification
- Peptide, Cell Wall Component
01
Overview
The D-Ala-D-Ala moiety is a dipeptide composed of two D-alanine residues. It forms the C-terminal end of the peptide stem attached to N-acetylmuramic acid (MurNAc) in peptidoglycan precursor subunits, which are essential building blocks for bacterial cell wall synthesis. It is a crucial substrate for transpeptidase enzymes, and a target for antibiotics like vancomycin.
- Other names
- D-Ala-D-Ala dipeptideD-alanyl-D-alanine moietyPeptidoglycan precursor terminus
02
Mechanism of action
Vancomycin binds directly to the D-Ala-D-Ala moiety, blocking transpeptidases. β-lactam antibiotics inhibit penicillin-binding proteins (transpeptidases) that interact with D-Ala-D-Ala.
03
Biological functions
Peptidoglycan biosynthesisCell wall cross-linkingSubstrate for transpeptidases
04
Disease associations
Bacterial infection
05
Safety considerations
Development of antibiotic resistance via alteration of the D-Ala-D-Ala sequence (e.g., to D-Ala-D-Lac or D-Ala-D-Ser)
06
Interacting drugs
Vancomycin
2 more in the full profile.
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