Gosset Molecular Classification
Membrane protein
Other Names
RhD Antigen, CD240D, Cluster designation: CD240D, RHDVA(TT), RHDel, RHPII
Disease Roles
D Antigen Overview
The D antigen, also known as the RhD antigen, is a protein found on the surface of red blood cells (RBCs). It is the most clinically significant and immunogenic antigen in the Rh blood group system. Presence or absence of this antigen determines whether an individual’s blood type is classified as RhD positive or negative. While not fully understood, evidence suggests that members of the broader Rh family function in gas transport across membranes—possibly ammonia or carbon dioxide. Loss of all components in this complex leads to abnormal RBC shape, increased fragility, shortened lifespan, and mild hemolytic anemia.
Mechanism of Action
Biological Functions
Membrane integrity
Possible role in ammonia transport
Possible role in carbon dioxide transport
Disease Associations
Hemolytic Disease of the Fetus and Newborn (HDFN)
Transfusion reactions
Hemolytic anemia
Safety Considerations
- Alloimmunization
- Hemolytic transfusion reactions
- Hemolytic disease of fetus/newborn (HDFN)
Associated Biomarkers
| Biomarker |
|---|
| RhD antigen presence or absence as a determinant of blood type |