DEAD-box helicase 11 (DDX11) (DDX11)

DEAD-box helicase 11 (DDX11), also known as CHLR1, is an ATP-dependent DNA helicase essential for maintaining genomic stability and ensuring proper chromosome segregation (UniProt Q96RR1). It plays a critical role in the establishment of sister chromatid cohesion during the S phase of the cell cycle and is involved in various DNA repair pathways, including the bypass of DNA lesions and the restart of stalled replication forks (NCBI Gene ID: 1663). In humans, biallelic mutations in the DDX11 gene result in Warsaw breakage syndrome, a rare genetic disorder characterized by microcephaly, growth retardation, and cellular hypersensitivity to DNA cross-linking agents (PMID: 20473300). DDX11 is frequently overexpressed in multiple malignancies, such as melanoma, osteosarcoma, and hepatocellular carcinoma, where it promotes tumor cell proliferation and survival (PMID: 26941568). Because of its elevated expression in cancer and its role in replication stress response, DDX11 is considered an emerging therapeutic target. Current experimental strategies often involve targeting DDX11 mRNA through RNA interference (siRNA or shRNA) to deplete the protein and induce mitotic catastrophe or sensitize cells to chemotherapy. Small molecule inhibitors targeting its helicase or ATPase activity are also under investigation as potential anti-cancer agents.

Other names

CHL1CHLR1KRGWarsaw breakage syndrome proteinDEAD/H box polypeptide 11DDX11 mRNA

Reduction of DDX11 protein levels via RNA interference (siRNA/shRNA) or potential small molecule inhibition of its ATP-dependent helicase activity to disrupt DNA replication and sister chromatid cohesion.