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Target intelligence / Profile preview
Deazaflavin-dependent Nitroreductase (Ddn)
- Target
- Ddn
- Molecular classification
- Enzyme, Oxidoreductase, Nitroreductase
01
Overview
Deazaflavin-dependent nitroreductase (Ddn) is an enzyme found in *Mycobacterium tuberculosis* that activates nitroimidazole prodrugs like PA-824 (pretomanid), contributing to the treatment of tuberculosis. Ddn catalyzes the reduction of these compounds using the deazaflavin cofactor F420H2, leading to the intracellular release of reactive nitrogen species lethal to mycobacterial cells. Besides drug activation, Ddn also functions natively as an F420H2-dependent menaquinone reductase in mycobacterial electron transport chains, contributing to energy generation and oxidative stress defense.
02
Mechanism of action
Reduction of nitroimidazole drugs, leading to the release of reactive nitrogen species.
03
Biological functions
Prodrug activationElectron transportMenaquinone reductase activityAntioxidant activityRedox reaction
04
Disease associations
InfectionTuberculosis
05
Safety considerations
Potential for off-target effects if Ddn homologs exist in other organisms.Resistance mechanisms involving Ddn mutations could emerge.
06
Interacting drugs
PA-824
2 more in the full profile.
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