Target intelligence / Profile preview

Decaprenyl-phosphoribose 2'-epimerase

Molecular classification: Enzyme

Overview

Decaprenyl-phosphoribose 2'-epimerase is an essential enzyme complex in mycobacteria, particularly *Mycobacterium tuberculosis*. It catalyzes the epimerization of decaprenylphosphoryl-β-D-ribose (DPR) to decaprenylphosphoryl-β-D-arabinofuranose (DPA), a critical step in the biosynthesis of cell wall components such as arabinogalactan and lipoarabinomannan (LAM). The enzyme complex consists of two subunits: DprE1 and DprE2. Inhibition of this enzyme disrupts cell wall synthesis, leading to bacterial death.

Mechanism of action

Inhibition of cell wall biosynthesis

Biological functions

Cell wall biosynthesisArabinofuranose donor production

Disease associations

Infection

Interacting drugs

Benzothiazinones (BTZs)

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