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Target intelligence / Profile preview
Decaprenylphosphoryl-beta-D-ribose 2'-epimerase
- Molecular classification
- Enzyme, Oxidoreductase, Flavoenzyme, Reductase
01
Overview
Decaprenylphosphoryl-beta-D-ribose 2'-epimerase (DprE1/DprE2 complex) is an essential enzyme in mycobacteria, including Mycobacterium tuberculosis, responsible for synthesizing decaprenylphosphoryl arabinose (DPA), a crucial precursor for cell wall components. It catalyzes the epimerization of decaprenylphosphoryl-beta-D-ribose (DPR) to DPA. As it's absent in humans, it's a validated drug target for anti-tubercular agents. Inhibition disrupts cell wall biosynthesis, leading to bacterial death.
- Other names
- DprE1Rv3790DprE2Rv3791
02
Mechanism of action
Inhibition of cell wall biosynthesis via covalent modification of DprE1
03
Biological functions
Cell wall biosynthesisArabinose metabolismDecaprenylphosphoryl arabinose (DPA) synthesis
04
Disease associations
InfectionTuberculosis
05
Interacting drugs
Benzothiazinones (BTZs)
1 more in the full profile.
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