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Target intelligence / Profile preview
Decaprenylphosphoryl-beta-D-ribose 2'-oxidase (DprE1)
- Target
- DprE1
- Molecular classification
- Enzyme, Oxidoreductase, Flavoenzyme
01
Overview
Decaprenylphosphoryl-beta-D-ribose 2'-oxidase (DprE1) is an essential flavoenzyme in Mycobacterium tuberculosis involved in the biosynthesis of decaprenyl-phospho-arabinose (DPA), a precursor for cell wall components lipoarabinomannan and arabinogalactan. DprE1 catalyzes the FAD-dependent oxidation of decaprenyl-phospho-ribose (DPR) to decaprenyl-phospho-2'-keto-D-arabinose (DPX), a key intermediate in DPA synthesis. It is a validated drug target for tuberculosis.
- Other names
- Decaprenylphosphoryl-beta-D-ribofuranose 2'-epimeraseRv3790DprE1trans,octacis-decaprenylphospho-beta-D-ribofuranose:FAD 2-oxidoreductase
02
Mechanism of action
FAD-dependent oxidation at the C2' position of DPR
03
Biological functions
Cell wall biosynthesisArabinan biosynthesisLipoarabinomannan biosynthesisCatalysisOxidation-reduction
04
Disease associations
InfectionTuberculosis
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