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Decaprenylphosphoryl-D-ribose 2'-epimerase subunit E2
- Molecular classification
- Enzyme
01
Overview
DprE2 is an essential enzyme in the biosynthetic pathway of mycobacterial cell wall components, specifically involved in the synthesis of decaprenylphosphoryl-D-arabinose (DPA). DPA serves as a lipid-linked arabinose donor required for constructing key cell wall polysaccharides such as arabinogalactan and lipoarabinomannan, which are crucial for the integrity and viability of Mycobacterium tuberculosis (Mtb). DprE2 forms a heteromeric membrane-bound epimerase complex with another enzyme, DprE1, and catalyzes the reduction step in the epimerization of decaprenylphosphoryl-D-2-keto-ribose (DPX) to DPA, utilizing NADH or NADPH as cofactors. Clinically relevant anti-tubercular drugs such as delamanid and pretomanid target this enzyme complex.
- Other names
- DprE2Rv3791
02
Mechanism of action
Inhibition of decaprenylphosphoryl-D-arabinose (DPA) synthesis, leading to defective cell wall biogenesis
03
Biological functions
Cell wall biosynthesisLipid metabolismPrecursor supply for arabinogalactan/lipoarabinomannan synthesisEpimerization
04
Disease associations
InfectionTuberculosis
05
Interacting drugs
Delamanid
1 more in the full profile.
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