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Target intelligence / Profile preview
Delta(9)-tetrahydrocannabinol (THC)
- Target
- THC
- Molecular classification
- Polycyclic terpenoid, Cannabinoid
01
Overview
Delta(9)-tetrahydrocannabinol (THC) is the principal psychoactive constituent of cannabis. In the intestinal tract, THC primarily interacts with cannabinoid receptors, influencing motility, secretion, and barrier function. It acts as a partial agonist at CB1 receptors located on enteric neurons, inhibiting acetylcholine release and slowing motility. THC also modulates serotonin signaling via antagonism at 5HT3 receptors, contributing to antiemetic properties. Metabolism occurs mainly in the liver by cytochrome P450 enzymes, resulting in active and inactive metabolites. THC is relevant for the management of chemotherapy-induced nausea/vomiting and potentially for modulating abnormal GI motility disorders and inflammatory bowel diseases.
- Other names
- Δ⁹-THC
02
Mechanism of action
Partial agonism at cannabinoid receptors (CB1, CB2), Weak antagonist at 5HT3 receptors
03
Biological functions
Modulation of gastric emptyingModulation of intestinal motilityAntiemeticImmunomodulation
04
Disease associations
Nausea and vomitingIrritable bowel syndrome (IBS)Functional dyspepsiaInflammatory bowel disease (IBD)
05
Safety considerations
Psychoactive effectsPotential for abuseDelayed gastric emptying
06
Interacting drugs
Cannabinoid receptor agonists
1 more in the full profile.
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