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Target intelligence / Profile preview
Dendritic Cell (Antigen Presentation) (DC)
- Target
- DC
- Molecular classification
- Leukocyte, Immune cell
01
Overview
Dendritic cells (DCs) are bone marrow-derived leukocytes and are considered the most efficient professional antigen-presenting cells (APCs) in the immune system. Their primary function is to process and present antigens on their surface to T cells, thereby acting as messengers between the innate and adaptive immune systems. DCs play a central role in initiating adaptive immune responses, determining tolerance, and regulating immunity against pathogens, tumors, and self-antigens.
- Other names
- Antigen-presenting cellAPC
02
Mechanism of action
Dendritic cells are targeted to enhance antigen presentation and T cell activation for cancer immunotherapy, or to induce tolerance in autoimmune diseases.
03
Biological functions
Antigen uptakeAntigen processingAntigen presentationT cell activationImmune response initiationImmune tolerance inductionMigration to lymphoid organs
04
Disease associations
CancerAutoimmune diseasesInfectionInflammation
05
Safety considerations
Cytokine stormOff-target immune activationAutoimmunity
06
Interacting drugs
Cancer vaccines
1 more in the full profile.
07
Biomarkers
MHC expression levelsCo-stimulatory molecule expression (CD80, CD86)CCR7 expressionCytokine production
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