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Dendritic Cell (via CD1d Presentation)
- Molecular classification
- Antigen-presenting cell, CD1d presentation pathway
01
Overview
Dendritic cells (DCs) present lipid antigens to iNKT cells via the CD1d molecule. This pathway bridges innate and adaptive immunity. CD1d is a non-polymorphic MHC class I-like molecule expressed on DCs and other cell types. DCs acquire glycolipid/lipid antigens, load them onto CD1d in lysosomes, and present the complex to iNKT cells. Activation of iNKT cells leads to cytokine secretion and modulation of downstream immune responses. This pathway is relevant to tumor immunity, infection, and autoimmunity.
02
Mechanism of action
Activation of iNKT cells via CD1d-antigen complexes.
03
Biological functions
Antigen presentationActivation of iNKT cellsModulation of B and T cell responsesInnate and adaptive immunity bridge
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Disease associations
Tumor immunityInfection controlAutoimmunityVaccine responsiveness
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Safety considerations
Potential for cytokine storm due to iNKT cell activationRisk of autoimmunity induction or exacerbation
06
Interacting drugs
alpha-galactosylceramide (alpha-GalCer)
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