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Dengue Virus Antigen (All Serotypes) (None)
- Target
- None
- Molecular classification
- Viral Protein, Nonstructural Protein, Structural Protein, Glycoprotein
01
Overview
Dengue virus antigens refer to the viral proteins produced by all four serotypes of dengue virus (DENV-1, DENV-2, DENV-3, and DENV-4). The main antigenic targets used for detection and diagnosis include: Nonstructural Protein 1 (NS1) and Envelope Protein (E). Detection of dengue antigens—especially NS1—is widely used in diagnostic assays to confirm acute infection before antibody responses develop fully. Secondary infections with a different serotype increase the risk for severe disease due to antibody-dependent enhancement.
- Other names
- DENV AntigensDengue Virus ProteinsNS1 ProteinEnvelope Protein E
02
Mechanism of action
N/A
03
Biological functions
Viral ReplicationImmune EvasionHost Cell EntryAntigen Presentation
04
Disease associations
Dengue FeverDengue Hemorrhagic Fever (DHF)Dengue Shock Syndrome (DSS)Infection
05
Safety considerations
Antibody-dependent enhancement (ADE) in secondary infectionsCross-reactivity of antibodies with other flaviviruses
06
Biomarkers
NS1 antigen (early acute infection marker)IgG/IgM antibodies (past or present infection)
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