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Target intelligence / Profile preview
Detoxified Escherichia coli Heat-Labile Enterotoxin LTh(αK) (LTh(αK))
- Target
- LTh(αK)
- Molecular classification
- Toxin, Adjuvant, Immunomodulator
01
Overview
Detoxified Escherichia coli heat-labile enterotoxin LTh(αK) is a genetically or chemically detoxified form of the heat-labile enterotoxin (LT) from *Escherichia coli* used as an immunomodulatory agent. It acts as a strong mucosal adjuvant, enhancing antigen-specific IgA responses and modulating dendritic cell maturation, promoting Th2-to-Th1 balance shift, and suppressing excessive inflammatory responses. It has potential for mucosal vaccine adjuvants, allergy immunotherapy, and asthma treatment.
- Other names
- Detoxified E. coli heat-labile enterotoxinLT mutantLTS61K (similar)Heat-labile enterotoxin mutant
02
Mechanism of action
Immune modulation via dendritic cell maturation inhibition and increased IgA response.
03
Biological functions
Immune modulationAdjuvant activityDendritic cell maturation modulationIgA response enhancementTh1/Th2 balance regulation
04
Disease associations
AllergyAsthmaVaccine adjuvant
05
Safety considerations
Potential for residual toxicityOff-target immune effectsRisk of inducing autoimmunity
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