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Dietary carbohydrate substrates in the GI tract refer principally to starches and other polysaccharides present in food that are hydrolyzed by amylase enzymes (salivary and pancreatic) into smaller sugars such as maltose and glucose, facilitating energy absorption and metabolic homeostasis. The efficient digestion of these carbohydrates is essential for normal nutritional physiology, and impairment of amylase activity or excessive intake of these substrates can be clinically relevant in conditions like obesity, diabetes, and metabolic syndrome. These substrates are not direct therapeutic targets; rather, enzymes like amylase are the relevant molecular targets for drugs that modify carbohydrate digestion.
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