DiGeorge syndrome critical region gene 5 (non-protein coding) (DGCR5)

DiGeorge syndrome critical region gene 5 (non-protein coding) (DGCR5) is a long non-coding RNA located on chromosome 22q11.2 within a region associated with DiGeorge and Velocardiofacial syndromes. DGCR5 regulates alternative splicing and acts via direct interaction with splicing factors, especially SRSF1, to promote cell proliferation, migration, invasion, and inhibit apoptosis in certain cancers. Its expression is regulated by REST and can act as either an oncogene or a tumor suppressor, depending on tumor type. DGCR5 is a biomarker for poor prognosis in cancers such as esophageal squamous cell carcinoma, and an early biomarker in Huntington’s disease. No drugs are currently reported to target DGCR5 directly, and its dual role in various cancers poses challenges to therapeutic targeting strategies.

Other names

LINC00037NCRNA00037X91348DGS-ADGS-BRIPPOM121L5PDGCR9DGCR10DiGeorge syndrome critical region gene 10 (non-protein coding)DiGeorge syndrome critical region gene 9 (non-protein coding)DiGeorge syndrome gene ADiGeorge syndrome gene BNon-protein coding RNA 37Long intergenic non-protein coding RNA 37Rac1 inactivated peptideCadherin EGF LAG seven-pass G-type receptor 1 pseudogene

Not applicable; as of now, no direct drugs target DGCR5. Its biological effects are mediated by modulation of splicing factors and downstream gene regulation (e.g., stabilization of SRSF1 and influence on Mcl-1 isoform production).