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Target intelligence / Profile preview
Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH)
- Target
- DHODH
- Molecular classification
- Enzyme, Flavoprotein
01
Overview
Dihydroorotate dehydrogenase (quinone), mitochondrial (DHODH) is a flavoprotein enzyme located in the inner mitochondrial membrane. It catalyzes the fourth step in de novo pyrimidine biosynthesis, converting dihydroorotate to orotate using quinone as an electron acceptor. DHODH is essential for producing uridine monophosphate (UMP), a precursor for all pyrimidine nucleotides. Mutations in DHODH cause Miller syndrome. DHODH inhibition has been explored therapeutically for cancer, immunological disorders, and infectious diseases.
- Other names
- DHOdehaseDihydroorotate oxidasePYRD_HUMANURA1 homolog
02
Mechanism of action
Inhibition of dihydroorotate dehydrogenase, leading to decreased pyrimidine biosynthesis.
03
Biological functions
Pyrimidine de novo biosynthesisCell proliferationCellular energy productionRedox balance
04
Disease associations
Miller syndromeCancerAutoimmune disordersInfectious diseases
05
Safety considerations
Immunosuppression (with leflunomide and teriflunomide)Teratogenicity (with leflunomide)
06
Interacting drugs
Leflunomide
2 more in the full profile.
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