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Target intelligence / Profile preview
Dihydropteroate Synthase (Plasmodium falciparum) (DHPS)
- Target
- DHPS
- Molecular classification
- Enzyme
01
Overview
Dihydropteroate synthase (DHPS) is a key enzyme in the folate biosynthesis pathway of *Plasmodium falciparum*, the parasite responsible for the most severe form of human malaria. DHPS catalyzes the condensation of para-aminobenzoic acid (pABA) with dihydropterin pyrophosphate to produce dihydropteroate, a precursor for folic acid derivatives essential for DNA synthesis and cell division in the parasite. It is a target for sulfa drugs like sulfadoxine. Resistance to these drugs arises from point mutations within the dhps gene that reduce drug binding affinity without abolishing enzymatic function.
02
Mechanism of action
Competitive inhibition at pABA site
03
Biological functions
Folate biosynthesisNucleotide biosynthesis
04
Disease associations
Infection
05
Safety considerations
Drug resistanceReduced treatment efficacy
06
Interacting drugs
Sulfadoxine
2 more in the full profile.
07
Biomarkers
dhps A437G mutationdhps mutations
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